Glad you asked...
Most lizards in the U.S. are pretty harmless, but you don't want them in your home. People don't bother to exterminate them but simply drive them away from their homes. The best way to do this is by spraying bug repellent. Cutting off their food supply will usually make them go away. You can also spray the perimeter of your house wit a concoction of tobasco sauce. This will usually drive them away for good.

